OUr RESEARCH Projects
Neurocognitive correlates of self-blaming biases as predictors of recurrence risk in depression
We have been very grateful for funding from the Medical Research Council UK (MRC Clinician Scientist Fellowship to Roland Zahn) which has enabled us to extend our research on the neural basis of self-blaming biases and their role in explaining vulnerability to major depression. The project was completed in the summer of 2015 and has led to multiple publications. We are grateful to have received another MRC-grant which seeks to replicate our finding that neurocognitive signatures of self-blaming biases predicted risk of recurrence in remitted MDD with over 80% accuracy. The new project has started in June 2021.
fMRI neurofeedback to tackle self-blaming biases in depression
Our fMRI neurofeedback trials to tackle self-blame in symptomatic (NeuroMooD pre-publication) and asymptomatic depression (NeuroImage Clinical paper ) funded by the D'Or Institute for Research and Education and the Brain & Behavior Research Foundation were completed and showed promising results which will need further work though to enable clinical translation.
Personalised treatments and decision support systems
Our work on the Computerised Antidepressant Advisor Decision Support System ( ADeSS Trial Protocol paper ) and the associated Mobile App (MooDoC ), as well as fMRI and Virtual Reality predictors (ADeSS-recruitment) of prognosis in primary care and response to treatment are ongoing.